Acid-PEG3-PFP ester one 3-O-α-rhamnosyl-(1→2)-β-glucoside Balb/c mice bearing CT26 tumors

Balb/c mice bearing CT26 tumors are treated with TBK1/IKKε-IN-1(compound 1) ± anti-PD-L1

and reduces the number and the size of lung metastases

Smiles: CC1(C)C[C@H]2C3=CC[C@H]4[C@@](C)(CC[C@H]5[C@@](C)([C@@H](O[C@@H]6O[C@H](CO)[C@@H](O)[C@H](O)[C@H]6O)[C@@H](O)C[C@@]54C)C(O)=O)[C@@]3(CC[C@]2(CC1)C(=O)O[C@@H]1O[C@H](C)[C@H](OC(=O)/C=C/C2=CC(OC)=C(OC)C(=C2)OC)[C@H](O)[C@H]1O[C@@H]1O[C@@H](C)[C@H](O[C@@H]2OC[C@@H](O)[C@H](O[C@@H]3OC[C@H](O)[C@H](O)[C@H]3O)[C@H]2O)[C@@H](O[C@@H]2OC[C@](O)(CO)[C@H]2O)[C@H]1O)CO

Formula: C18H24ClNO3

C1CN(CCN1)C1=CC=CC2C=CC=CC=21

Acid-PEG3-PFP ester one 3-O-α-rhamnosyl-(1→2)-β-glucoside Balb/c mice bearing CT26 tumorsAcid PEG3 PFP ester is a PEG based PROTAC linker that can be used in the synthesis of PROTACs. Product information CAS Number: 1835759 67 5 Molecular Weight: 416. 29 Formula: C16H17F5O7 Chemical Name: 3 (2 {2 [3 oxo 3 (2,3,4,5,6 pentafluorophenoxy)propoxy]ethoxy}ethoxy)propanoic acid Smiles: OC(=O)CCOCCOCCOCCC(=O)OC1C(F)=C(F)C(F)=C(F)C=1F InChiKey: QFILSUVCEHSYOO UHFFFAOYSA N InChi: InChI=1S C16H17F5O7 c17 11 12(18)14(20)16(15(21)13(11)19)28 10(24)2 4